News and press

Individuals with BSEP deficiency with one p.E297G or p.D482G mutation and one PPTM have a similarly severe disease course and low responsiveness to siEHC as those with two PPTMs.

Featuring new scientific work with internationally-known speakers, expert panels, early career investigators, and audience participation.

The new office is located in the Metro DC area near clients and partners, offering convenience for meetings and collaboration.

Dr. Stanik to assist Arbor Research with further expansion into long-term care, behavioral health, and mixed methods research

Using a mouse model of BA and human liver gene expression data collected by ChiLDReN, we were able to confirm the likely activation of this pathway known as TWEAK/FN14 in association with liver fibrosis. We further showed that inhibition of this pathway pharmacologically was associated with near complete elimination of fibrosis in the mouse model of BA.

Arbor Research will support AHRQ in developing their patient centered outcomes research trust fund (PCORTF) strategic plan, logic model, and theory of change.

Dr. Roberto Pecoits-Filho will lead as the scientific and clinical leader of the world-renowned Dialysis Outcomes and Practice Patterns Study (DOPPS).

Arbor Research will work closely with the Centers for Disease Control and Prevention’s National Healthcare Safety Network to evaluate the ability of electronic health record (EHR) vendors to successfully implement and disseminate a standardized system for Clostridioides difficile infection (CDI) reporting into their EHR system, and assess the concordance of EHR versus manual-based reporting of CDIs by nursing homes.

Arbor Research will collaborate with prime contractor Lewin Group, as well as with the University of Michigan Kidney Epidemiology and Cost Center and ICF to assess the effectiveness of each model.

Large-scale proteomics identified SEMA6B, SFRP3, COMMD7, BMX, and VCAM1 as biomarkers highly associated with clinical portal hypertension in children with biliary atresia. The expression of the biomarkers in liver epithelial, endothelial, and immune cells support their potential role in the mechanisms that cause portal hypertension.

Study partnership will address disparities in hypertension control among racial and ethnic minority populations

Leader in broad-based finance and government contracting, Chauncey Lynch appointed to head Arbor Research finance team

Experienced business development professional Shanthy Edward, M.A., Psy.D. joins Arbor Research as Vice President of Strategic Growth & Chief Growth Officer.

Leaders in public health and social justice, Deborah Klein Walker, EdD, Med, BA and Gerald M. Croan, SB, MCP join Arbor Research’s Board of Directors

Seasoned business leader and researcher, Chris Spera, Ph.D, takes the helm at Arbor Research, succeeding retiring president, Robert M. Merion, M.D. FACS.

The Dialysis Outcomes and Practice Patterns (DOPPS) Program has expanded the DOPPS Practice Monitor (DPM) to include peritoneal dialysis (PD). The DPM-PD now reports the most up-to-date trends in care for patients receiving chronic PD in the US.

In a 1-year-old female patient with normal GGT cholestasis and bile duct paucity, we identified a homozygous truncating pathogenic variant (c.198delA, p.Gly67Alafs∗6) in the ABCC12 gene (NM_033226). Five additional rare ABCC12 variants, including a pathogenic one, were detected in our cohort.

Using data from the United States Renal Data System (USRDS), our researchers calculated access procedure (intervention) rates in the US for patients starting hemodialysis with an AVF or AVG created during their first year of hemodialysis therapy between July 1, 2012 and December 31, 2014 (N = 73,027).

Regional variation in glutathione metabolism underlies sensitivity to the biliary toxin biliatresone and may account for the reported association between BA transplant-free survival and glutathione metabolism gene expression.

Dr. Robert M. Merion, MD, FACS has announced that he will step down as President and Chief Executive Officer of Arbor Research Collaborative for Health by August 2021.

Our finding of de novo variants in genes linked to evolutionarily conserved stress responses (STIP1 and REV1) suggests that exploration of how genetic susceptibility and environmental exposure may interact to cause BA is warranted.

Our collaborator on the National Living Donor Assistance Center (NLDAC) project, Amit Mathur, MD, transplant surgeon at the Mayo Clinic of Arizona, has been selected to receive the prestigious 2020 Vanguard Award from the American Society of Transplant Surgeons (ASTS), in recognition of his recent publication in Clinical Transplantation, “Return on investment for financial assistance for living kidney donors in the United States.”

In studies of liver tissues from infants with cholestasis, we identified a 14-gene expression pattern that associated with transplant-free survival for 2 years.

How distress from itchy skin impacts patient health and quality of life

Generic medications reduce the lifetime costs of organ transplantation